Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications in drug delivery

نویسندگان

چکیده

Abstract The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest significant entrants in development of drug delivery systems owing to their myriad advantages. NLCs second-generation SLNs having unstructured matrix, have high loading, provide long-term stability comparison other systems, which show lower loading experience burst release/drug expulsion during storage. This review is aimed summarize formulation optimization strategies for reported literature collected from authentic databases. Various types NLCs, components, methods preparation, characterization parameters, (statistical designs) strategies, toxicity, regulatory aspects, applications oral, parenteral, ocular, pulmonary, nose-to-brain, tumor targeting, transdermal been dealt detail. Patents granted on also enlisted.

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ژورنال

عنوان ژورنال: Nanotechnology reviews

سال: 2022

ISSN: ['2191-9097', '2191-9089']

DOI: https://doi.org/10.1515/ntrev-2022-0109